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2011
IEEE

Differential information content in staggered multiple shell hardi measured by the tensor distribution function

10 years 12 months ago
Differential information content in staggered multiple shell hardi measured by the tensor distribution function
Diffusion tensor imaging has accelerated the study of brain connectivity, but single-tensor diffusion models are too simplistic to model fiber crossing and mixing. Hybrid diffusion imaging (HYDI) samples the radial and angular structure of local diffusion on multiple spherical shells in qspace, combining the high SNR and CNR achievable at low and high b-values, respectively. We acquired and analyzed human multi-shell HARDI at ultra-high field-strength (7 Tesla; b=1000, 2000, 3000 s/mm2 ). In experiments with the tensor distribution function (TDF), the b-value affected the intrinsic uncertainty for estimating component fiber orientations and their diffusion eigenvalues. We computed orientation density functions by least-squares fitting in multiple HARDI shells simultaneously. Within the range examined, higher b-values gave improved orientation estimates but poorer eigenvalue estimates; lower b-values showed opposite strengths and weaknesses. Combining these strengths, multiple-shell HA...
Liang Zhan, Alex D. Leow, Iman Aganj, Christophe L
Added 21 Aug 2011
Updated 27 Dec 2012
Type Journal
Year 2011
Where ISBI
Authors Liang Zhan, Alex D. Leow, Iman Aganj, Christophe Lenglet, Guillermo Sapiro, Essa Yacoub, Noam Harel, Arthur W. Toga, Paul M. Thompson
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